0.2-0.5g of fresh frozen LM tissues (patient number = 5) were used for ChIP-Seq using the SimpleChIP Kit (Cell Signaling Technology, #9005). PGR antibody was purchased from Santa Cruz (#sc-7208X). Next-generation sequencing libraries were prepared using the KAPA Hyper Prep Kit (KAPA Biosystems, KK8502) and KAPA Single-Indexed Adapter Kit (KAPA Biosystems, KK8710).